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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Creating an in-vitro model system for studying phase separation in virus assembly
 WIENER, Katharina
This thesis focuses on the study of the ?NS protein of the avian reovirus and as this virus is causing considerable annual losses in the poultry industry, understanding its replicative cycle on a molecular basis is highly anticipated. One area of interest is hereby the formation of so-called viroplasms via liquid-liquid phase separation (LLPS) of the ?NS protein. The exact processes involved in LLPS, however, remain mostly unknown. By establishing an in-vitro model system we tried to elucidate the environmental conditions needed for phase separation, in order to gain a better understanding of the viral replicative cycle, as well as LLPS in general.
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Membraneless organelles in eukaryotic cells
 Beránková, Pavla ; Libusová, Lenka (advisor) ; Bařinka, Cyril (referee)
Membraneless organelles (MLOs) are a newly described type of cellular compartments. They consist of protein and nucleic acid molecules that undergo liquid-liquid phase separation (LLPS). MLOs are able to fulfill unique biological roles, because they are highly dynamic and their composition can be effectively regulated. Composition and function of these formations are swiftly being elucidated. The work summarizes the basic principles of LLPS in living organisms and further focuses on several types of MLOs functionally connected to microtubules (MTs). Their recurrent feature is the ability to nucleate MTs. This eventual role corresponds well with their high temporal and spatial dynamics.
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